Convergent roles of de novo mutations and common variants in schizophrenia in tissue-specific and spatiotemporal co-expression network

P Jia, X Chen, AH Fanous, Z Zhao - Translational psychiatry, 2018 - nature.com
… could presumably replenish the genetic variants that are wiped … We introduced a schizophrenia
gene network that could … characterized genes harboring different types of variants and …

Convergence and divergence in the genetics of psychiatric disorders from pathways to developmental stages

S Shohat, A Amelan, S Shifman - Biological psychiatry, 2021 - Elsevier
… risk factors for major neuropsychiatric disorders (schizophreniafunctional convergence
most relevant to a specific condition will likely be shared across different types of genetic variants

Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia

M Kim, JR Haney, P Zhang, LM Hernandez… - Nature …, 2021 - nature.com
genetic variation within the C4 locus 9 . In humans, C4 is encoded by two genes—C4A and
C4B—which exist in different … this network-based, brain-specific functional annotation for C4A …

Common and rare genetic risk factors converge in protein interaction networks underlying schizophrenia

X Chang, LA Lima, Y Liu, J Li, Q Li, PMA Sleiman… - … in genetics, 2018 - frontiersin.org
… Among the different types of gene networks, protein-protein interaction (PPI) networks have
… We hypothesize that a group of functionally related genes with nominal significance could …

Convergence and divergence of rare genetic disorders on brain phenotypes: a review

A Raznahan, H Won, DC Glahn… - JAMA psychiatry, 2022 - jamanetwork.com
… and effect sizes of genetic variation on autism spectrum … phenotypic convergence and
divergence between differentgenes in CNVs associated with ASD and schizophrenia with …

Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease

MR Johnson, K Shkura, SR Langley… - Nature …, 2016 - nature.com
… of genes intolerant to functional genetic variation relative to … M3 and schizophrenia but not
with common forms of epilepsy. … and common epilepsy include different gene contributions to …

Genetic identification of brain cell types underlying schizophrenia

NG Skene, J Bryois, TE Bakken, G Breen, JJ Crowley… - … genetics, 2018 - nature.com
… in knowledge about the genetic basis of schizophrenia have not converged on findings …
diverse gene sets previously associated with schizophrenia (genes involved in synaptic function

Convergent impact of schizophrenia risk genes

KG Townsley, A Li, PJM Deans, JF Fullard, A Yu… - bioRxiv, 2022 - biorxiv.org
… most frequently arises from common genetic variation that confers … functional similarity of
target genes impacts the degree of convergence, suggesting that risk variants sum in different

[PDF][PDF] Varying intolerance of gene pathways to mutational classes explain genetic convergence across neuropsychiatric disorders

S Shohat, E Ben-David, S Shifman - Cell reports, 2017 - cell.com
… spectrum disorder, and schizophrenia. Using systems biology … to genetic variations but that
spatiotemporal activity of genes … , while we see different patterns of enrichment for classes of …

New gene discoveries highlight functional convergence in autism and related neurodevelopmental disorders

M Moyses-Oliveira, R Yadav, S Erdin… - … Opinion in Genetics & …, 2020 - Elsevier
… points of convergence among these genes with diverse biological … fold enrichment for rare
inherited variants). This study reported 102 … associated with ASD, NDD, schizophrenia (SCZ), …