Convergent roles of de novo mutations and common variants in schizophrenia in tissue-specific and spatiotemporal co-expression network
… could presumably replenish the genetic variants that are wiped … We introduced a schizophrenia
gene network that could … characterized genes harboring different types of variants and …
gene network that could … characterized genes harboring different types of variants and …
Convergence and divergence in the genetics of psychiatric disorders from pathways to developmental stages
… risk factors for major neuropsychiatric disorders (schizophrenia… functional convergence
most relevant to a specific condition will likely be shared across different types of genetic variants …
most relevant to a specific condition will likely be shared across different types of genetic variants …
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia
… genetic variation within the C4 locus 9 . In humans, C4 is encoded by two genes—C4A and
C4B—which exist in different … this network-based, brain-specific functional annotation for C4A …
C4B—which exist in different … this network-based, brain-specific functional annotation for C4A …
Common and rare genetic risk factors converge in protein interaction networks underlying schizophrenia
… Among the different types of gene networks, protein-protein interaction (PPI) networks have
… We hypothesize that a group of functionally related genes with nominal significance could …
… We hypothesize that a group of functionally related genes with nominal significance could …
Convergence and divergence of rare genetic disorders on brain phenotypes: a review
… and effect sizes of genetic variation on autism spectrum … phenotypic convergence and
divergence between different … genes in CNVs associated with ASD and schizophrenia with …
divergence between different … genes in CNVs associated with ASD and schizophrenia with …
Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease
MR Johnson, K Shkura, SR Langley… - Nature …, 2016 - nature.com
… of genes intolerant to functional genetic variation relative to … M3 and schizophrenia but not
with common forms of epilepsy. … and common epilepsy include different gene contributions to …
with common forms of epilepsy. … and common epilepsy include different gene contributions to …
Genetic identification of brain cell types underlying schizophrenia
… in knowledge about the genetic basis of schizophrenia have not converged on findings …
diverse gene sets previously associated with schizophrenia (genes involved in synaptic function…
diverse gene sets previously associated with schizophrenia (genes involved in synaptic function…
Convergent impact of schizophrenia risk genes
… most frequently arises from common genetic variation that confers … functional similarity of
target genes impacts the degree of convergence, suggesting that risk variants sum in different …
target genes impacts the degree of convergence, suggesting that risk variants sum in different …
[PDF][PDF] Varying intolerance of gene pathways to mutational classes explain genetic convergence across neuropsychiatric disorders
… spectrum disorder, and schizophrenia. Using systems biology … to genetic variations but that
spatiotemporal activity of genes … , while we see different patterns of enrichment for classes of …
spatiotemporal activity of genes … , while we see different patterns of enrichment for classes of …
New gene discoveries highlight functional convergence in autism and related neurodevelopmental disorders
… points of convergence among these genes with diverse biological … fold enrichment for rare
inherited variants). This study reported 102 … associated with ASD, NDD, schizophrenia (SCZ), …
inherited variants). This study reported 102 … associated with ASD, NDD, schizophrenia (SCZ), …